ANTIMICROBIAL ACTIVITY OF LEAVES OF RUBUS ULMIFOLIUS SCHOTT AGAINST SOME PATHOGENIC BACTERIA AND FUNGI AND EVALUATION OF THE ACUTE TOXICITY

Abstract

The aqueous, methanolic  and phenolic extracts of Rubus  ulmifolius leaves were studied and tested for their antimicrobial  and antifungi activity against some clinical bacteria .Than the acute toxicity was evaluated. The results showed that the phenolic extract was the most active of staphylococcus aureus with a maximum zone of inhibition 7-12mm. All the other bacteria and fungi showed no significant susceptibility. Among, the acute oral toxicity investigation of aqueous extract shows no mortality and any evidence of adverse effects have been observed in mice following acute oral administration at the highest dose of 1,2g/ kg.