Synthesis, Preliminary Qsar Study And Anti-Bacterial Activity Of Some Novel 2, 3- Disubstituted Quinazolinone Derivatives

Authors

  • DR.K.GIRIJA Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute Of Health Sciences, (A Govt. Of Puducherry Institution), Puducherry, India.
  • K.HEMALATH Department of Pharmaceutical Chemistry, Mother Theresa Post Graduate and Research Institute Of Health Sciences, (A Govt. Of Puducherry Institution), Puducherry, India.

Keywords:

Synthesis, Quinazolinone derivatives, Anti-bacterial activity, p-amino compounds

Abstract

A series of novel quinazolinone derivatives have been synthesized by the condensation of 2substituted benzoxazine /6, 8-dibromo-2-substituted benzoxazine with p-amino containing compounds. Structures of the newly synthesized compounds have been established on the basis of their melting point, thin layer chromatography, IR and 1H-NMR data. All the newly synthesized quinazolinone derivatives were evaluated for their anti-bacterial activity by disc diffusion method by measuring the zone of inhibition and the results were compared to standard. 

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Published

31.12.2010

How to Cite

DR.K.GIRIJA, & K.HEMALATH. (2010). Synthesis, Preliminary Qsar Study And Anti-Bacterial Activity Of Some Novel 2, 3- Disubstituted Quinazolinone Derivatives. International Journal of Pharma and Bio Sciences, 1(4), 254–259. Retrieved from https://ijpbs.net/index.php/journal/article/view/355

Issue

Volume 1, Issue 4, 2010

Section

Research Articles