A STUDY ON THE LEVELS OF MDA AND SOD IN PRE AND POST DIALYSIS PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

The study was conducted on 50 chronic renal failure patients who were undergoing hemodialysis for atleast a period of 6 months. Samples were drawn before and after hemodialysis comprising of two groups A and B. Group C 50 age and gender matched healthy individuals were taken as controls. Serum Malondialdehyde (MDA) when estimated showed significant increase in postdialysis patients when compared with predialysis with p< 0.0001. Serum SOD showed a significant decrease in postdialysis patients when compared with predialysis with p< 0.001. Prooxidant serum MDA was high in patient groups pre and postdialysis, when compared to controls p<0.001, while antioxidant serum SOD was low in patient groups pre and postdialysis when compared to controls p<0.0001. In the present study, we observed that patients undergoing hemodialysis are subjected to oxidative stress, due to increase in oxidants and ineffective antioxidant defense mechanisms as shown by decreased serum SOD.