STUDIES ON DISSOLUTION BEHAVIOUR OF SUSTAINED RELEASE SOLID DISPERSIONS OF NIMODIPINE

Abstract

Among the various numbers of techniques available for controlled rate of release of drugs, controlling the rate of dissolution is very popular due to its success and economy. Though there are various reports on sustained action formulations, less number of studied s were reported on the use of this technique to produce sustained formulation.. The present study deals with the preparation and evaluation of sustained release solid dispersions of Nimodipine. The solid dispersions were prepared by solvent evaporation technique using EC, EU RL-100 and EVA as carriers in various ratios. Optimized sustained release solid dispersions were evaluated for drug content uniformity, I.R. and In-vitro drug release studies. The results showed that among the various batches containing the polymer being used in the study, F8 formulation containing DRUG: EU RL-100 in the ratio of 1:4 exhibited consistent release profile of the drug. The results were supported by Hardness, Friability, Weight variation, In-vitro drug release and stability studies.