ANTI-ULCER EFFECTS OF THE AQUEOUS EXTRACT OF AGERATUM CONYZOIDES LINN. IN ASPIRIN PLUS PYLORIC LIGATION INDUCED ULCER IN ALBINO RATS.

Abstract

The antiulcer effects of aqueous of Ageratum conyzoides was studied in aspirin plus pyloric ligation induced ulcer in albino rats. Animals were divided into 4 groups of 6 animals each Group I( control) received 1ml/200g of  2%gum acacia in distilled water, Group II(standard)- omeprazole 2mg/kg bodyweight),Group III (sub group I) received  test drug 200mg/kg bodyweight, (sub group II) received  test drug 400mg/kg bodyweight and all the groups received aspirin 200mg/kg bodyweight. All the drugs were suspended in 2% gum acacia in distilled water and given orally at a uniform volume of 1ml/200 gram daily for 5 days before pyloric ligation. The   anti ulcer effects  was evaluated by four parameters i.e ulcer index, pepsin activity, free and total acidity and gastric barrier mucus secretion. The test drug shows significant anti ulcer effects when compared with the control. The study shows that the aqueous extract of Ageratum conyzoides Linn have antiulcer effects which may be due to the presence of flavonoids in the plant.