AN OVERVIEW ON BILAYERED TABLET TECHNOLOGY

Abstract

Bi-layer tablet is a new era for successful development of controlled release formulation along with various features to provide successful drug delivery. Bilayer tablet is suitable for combination of separate two incompatible drug substances, also for sustained release tablet in which one layer is for immediate release as loading dose and second layer is maintenance dose. So use of bilayer tablet is a very different aspect for antihypertensive, anti-diabetic, anti-inflammatory and analgesic drug where combination therapy is often used. Bilayer tablet is improved beneficial technology to overcome the shortcoming of the single layered tablet. This article explains fundamentals of bilayer tablet system which include advantages, disadvantages, GMP requirements, various types of techniques and bilayer tablet press currently available in the market, manufacturing process, and tablet surface characterization by various imaging techniques, challenges in bilayer manufacturing, characterization as well as evaluation of the bilayer tablet system.