ANTIGEN PROTEIN FROM SCHISTOSOMA MANSONI: NEW PARADIGM OF SYNTHETIC VACCINE DEVELOPMENT

Authors

  • GOMASE V.S School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413531, MS, India, Mobile- 09987770696.
  • CHITLANGE N.R. School of Technology, S.R.T.M. University, Sub-Centre, Latur, 413531, MS, India, Mobile- 09987770696.

Keywords:

antigen protein, epitope, PSSM, SVM, MHC, peptide vaccine

Abstract

Schistosoma mansoni causative agent of schistosomiasis. Peptide fragments of antigen protein can be
used to select nonamers for use in rational vaccine design and to increase the understanding of roles
of the immune system in parasitic diseases. Analysis shows MHC class II binding peptides of antigen
protein from Schistosoma mansoni are important determinant for protection of host form parasitic
infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the
binding affinity of antigen protein having 393 amino acids, which shows 385 nonamers. Binding ability
prediction of antigen peptides to major histocompatibility complex (MHC) class I & II molecules is
important in vaccine development from Schistosoma mansoni.

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Published

30.09.2010

How to Cite

GOMASE V.S, & CHITLANGE N.R. (2010). ANTIGEN PROTEIN FROM SCHISTOSOMA MANSONI: NEW PARADIGM OF SYNTHETIC VACCINE DEVELOPMENT. International Journal of Pharma and Bio Sciences, 1(3), 1–7. Retrieved from https://ijpbs.net/index.php/journal/article/view/344

Issue

Volume 1, Issue 3, 2010

Section

Research Articles