FORMULATION & EVALUATION OF MELOXICAM SOLID DISPERSION INCORPORATED TOPICAL GELS

Abstract

Sustained releases tablets of Diltiazem hydrochloride were formulated by employing hydroxypropyl methylcellulose (HPMC K100 M) and the sustained release behaviour of the fabricated tablets was investigated. Sustained release matrix tablets containing 120 mg Diltiazem hydrochloride were developed using different drug: polymer (HPMC K100 M) ratios. Tablets were prepared by wet granulation technique. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The resulting formulation produced robust tablets with optimum hardness, consistent weight uniformity and low friability. All tablets but one exhibited gradual and near-complete sustained release for Diltiazem hydrochloride (96-100%) at the end of 24 h. The results of dissolution studies indicated that formulation B5 (drug to polymer 1:1.25) was found to be most successful as it exhibits drug release pattern very close to theoretical release profile. A decrease in release kinetics of the drug was observed on increasing polymer ratio.