SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW PYRIDINYL/QUINAZOLINYL/AZETIDINONYL/THIAZOLIDINONYL TRIAZOLES

Abstract

A series of N-(6-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-(3-chloro-2-(substitutedphenyl)-4-
oxoazetidin-1-yl)-5-(pyridin-4-yl)-5-thio)acetamido-1,2,4-triazoles (5a-5g) have been prepared by the
condensation of 6-bromo-2-methyl-4-oxoquinazolin-3(4H)-yl-2-(4-(substitutedbenzylideneamino)-5-(pyridin-4-
yl)-3-thio)acetamido-1,2,4-triazoles (4a-4g) with chloroacetyl chloride in presence of trimethylamine. N-(6-
bromo-2-methyl-4-oxoquinazolin-3(4H)-yl)-2-(4-(2-(substitutedphenyl)-4-oxothiazolidin-3-yl)-5-(pyridin-4-yl)-
3-thio)acetamido-1,2,4-triazoles (6a-6g) have been synthesized by the reaction of compounds 4a-4g with
thioglycolic acid in presence of anhydrous zinc chloride. All the newly synthesized compounds were screened
for their antibacterial activity against S.aureus, E.coli, P.vulgaris, K. pneumoniae. Structures of all the
compounds were established by elemental and spectral (IR, 1H NMR and Mass) analysis.