AN EXPERIMENTAL EVALUATION OF ANTICONVULSIVE EFFECTS OF CURCUMIN IN WISTAR RATS

Authors

  • DR. KRANTI TEKULAPALLY Resident Specialist, Gandhi Medical College, Secunderabad
  • DR. M.PURNA CHANDRAKALA Professor, Department of Pharmacology, Deccan College of Medical Sciences, Hyderabad.
  • DR. SHOBHANA MATHUR Professor & Head, Department of Pharmacology, Deccan College of Medical Sciences, Hyderabad.

Keywords:

Diazepam, Maximal Electroshock seizures, Phenytoin, Pentylenetetrazol

Abstract

Curcumin is the active coloring principle of Turmeric. In the present study, the anticonvulsive effect of Curcumin was studied in albino Wistar rats in two methods. First, Curcumin in a dose of 100mg/kg was tested in comparison to Phenytoin sodium by Maximal Electroshock Seizure (MES) method in which the Duration of Tonic hind limb extension was observed. Secondly, antiepileptic effect of Curcumin was compared to Diazepam in Pentylenetetrazol (PTZ) induced convulsions in which onset and severity of convulsions was observed. Results obtained were analyzed statistically by Kruskal Wallis test and Mann Whitney U test using spss 20.0.0 software. The results showed that Curcumin significantly reduced the duration of tonic hind limb extension with a p < 0.05 in MES model and In PTZ test, it increased the latency to the onset of seizures with p< 0.01. The anticonvulsive effect of Curcumin was thus comparable to the standard antiepileptic drugs

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Published

30.09.2014

How to Cite

DR. KRANTI TEKULAPALLY, DR. M.PURNA CHANDRAKALA, & DR. SHOBHANA MATHUR. (2014). AN EXPERIMENTAL EVALUATION OF ANTICONVULSIVE EFFECTS OF CURCUMIN IN WISTAR RATS. International Journal of Pharma and Bio Sciences, 5(4), 116–128. Retrieved from https://ijpbs.net/index.php/journal/article/view/3263

Issue

Volume 5, Issue 3, 2014

Section

Research Articles

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