INSILICO MODELLING OF THE INTEGRATIVE PATHWAY OF CARCINOMA BY HPV E6 PROTEIN–PROTEIN INTERACTION

Authors

  • JERRINE JOSEPH Centre for Drug Discovery and Development, Sathyabama University, Chennai, India.
  • HELEN MARY Department of Advanced Zoology and Bio Technology, Loyola College, Chennai, India.
  • D. SUDARSANAM Department of Advanced Zoology and Bio Technology, Loyola College, Chennai, India.

Keywords:

HPV 16, E6 protein, STRING database and cancer

Abstract

The Human papillomavirus (HPV) E6 protein is one of the oncoproteins encoded by the
virus. Inorder to understand the mechanism by which E6 interacts with the host cellular
proteins to trigger the cascade of cancer cell transformation. STRING (Search Tool for
the Retrieval of Interacting Genes/Proteins) is a biological database has been used to
model the pathway of the protein- protein interaction and how intimately they associate
to contribute to the malignancy of the HPV transformed cells. SIPA1L1, E6AP and
E6BP three individual annotated pathways enable to construct a putative pathway
using their annotations and in literature review. The E6 cellular target has important
implications for the development of effective cancer therapeutic strategies.

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Published

31.03.2014

How to Cite

JERRINE JOSEPH, HELEN MARY, & D. SUDARSANAM. (2014). INSILICO MODELLING OF THE INTEGRATIVE PATHWAY OF CARCINOMA BY HPV E6 PROTEIN–PROTEIN INTERACTION. International Journal of Pharma and Bio Sciences, 5(1), 1107–1111. Retrieved from https://ijpbs.net/index.php/journal/article/view/3232

Issue

Volume 5, Issue 1, 2014

Section

Research Articles

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