“COMPARATIVE STUDY OF HEPATOCELLULAR DYSFUNCTIONS BETWEEN PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX IN WEST BENGAL”.

Abstract

Aims: Our aim in this study was to compare the spectrum of hepatic damage between
plasmodium falciparum and vivax. Materials and methods: From 228 (114 each for
falciparum and vivax) diagnosed malaria patients, blood were collected for
hematological, biochemical and serological tests (to exclude other causes of hepatitis).
Data were collected and analyzed to compare severity between them. Results: In case
of vivax affected females, serum bilirubin were raised, albumin and total protein were
depressed significantly, whereas, in case of falciparum affected males, serum bilirubin,
SGPT, SGOT, alkaline phosphatase were raised and total protein, albumin decreased
significantly. In case of plasmodium falciparum affected patients, SGPT and alkaline
phosphatase were elevated, whereas, serum albumin and prothrombin time were
decreased significantly. In both groups, hemoglobin level was near normal. Conclusion:
Falciparum was responsible for severe hepatocellular dysfunction. Hence, early
detection of hepatic damage is necessary to prevent its future possible complications.