LYMPHANGIOGENESIS IN ORAL SQUAMOUS CELL CARCINOMA AND POTENTIALLY MALIGNANT ORAL LESIONS

Authors

  • SAUMYA CHANDRA Department of Pathology, King George’s Medical University, Lucknow
  • MADHU MATI GOEL Department of Pathology, King George’s Medical University, Lucknow
  • ANNU MAKKER Department of Pathology, King George’s Medical University, Lucknow
  • SEEMA NAYAK Department of Pathology, King George’s Medical University, Lucknow
  • PRIYANKA SHILPI Department of Pathology, King George’s Medical University, Lucknow
  • VIKRAM BHATIA Department of Pathology, King George’s Medical University, Lucknow
  • M.L.B. BHATT Department of Radiation Oncology Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow

Keywords:

Potentially malignant oral lesions (PMOLs), Epithelial Dysplasia, Malignant Transformation, Oral cancer, Lymph Node

Abstract

Podoplanin is a mucin-like glycoprotein that is important in lymphangiogenesis but not in
blood vessel formation. The aim of this study is to determine the role of podoplanin in
malignant transformation of PMOLs to oral cancer and in progression of oral cancer. In
this report, LVD defined as of podoplanin detected positive lymphatic vessels and MVD
as the density of CD-31 positive microvessels. The objectives of this study were to
clarify the clinical and prognostic significance of both LVD and MVD in PMOLs and oral
cancer. The current results suggested that LVD is a more useful tool than MVD. We can
conclude that podoplanin is involved in malignant transformation to oral cancer in
PMOLs patients and can be a predictor for lymph node metastasis in oral cancer
patients.

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Published

31.03.2014

How to Cite

SAUMYA CHANDRA, MADHU MATI GOEL, ANNU MAKKER, SEEMA NAYAK, PRIYANKA SHILPI, VIKRAM BHATIA, & M.L.B. BHATT. (2014). LYMPHANGIOGENESIS IN ORAL SQUAMOUS CELL CARCINOMA AND POTENTIALLY MALIGNANT ORAL LESIONS. International Journal of Pharma and Bio Sciences, 5(1), 983–993. Retrieved from https://ijpbs.net/index.php/journal/article/view/3216

Issue

Volume 5, Issue 1, 2014

Section

Research Articles

Categories

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