Determination of Some Antineoplastic Agents in the Pure Form and in Their Pharmaceutical Preparation with N-Bromosuccinimide Reagent

Authors

  • I.C. SHUKLA Department of Chemistry, University of Allahabad, Allahabad- India
  • VINOD KUMAR Department of Chemistry, University of Allahabad, Allahabad- India
  • B.K. SINGH Department of Chemistry, University of Allahabad, Allahabad- India
  • O.P. YADAV Department of Chemistry, University of Allahabad, Allahabad- India
  • SANJAI KUMAR Department of Chemistry, University of Allahabad, Allahabad- India

Keywords:

Antineoplastic agents, Pharmaceuticals, N-Bromosuccinimide and Titration

Abstract

A simple, quick and convenient method has been developed for the determination of some antineoplastic drugs like cyclophosphamide, chlorambucil, melphalan, busulphan, methotrexate, mercaptopurine and 5-fluorouracil in pure form and in their pharmaceutical preparation with the use of Nbromosuccinimide reagent. The value of percentage error, coefficient of variation (CV) and standard deviation (SD) prove the method to be precise and reproducible. To establish authenticity of the method, recovery experiments were also carried out by standard drug addition method. 

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Published

30.06.2010

How to Cite

I.C. SHUKLA, VINOD KUMAR, B.K. SINGH, O.P. YADAV, & SANJAI KUMAR. (2010). Determination of Some Antineoplastic Agents in the Pure Form and in Their Pharmaceutical Preparation with N-Bromosuccinimide Reagent. International Journal of Pharma and Bio Sciences, 1(2), 1–11. Retrieved from https://ijpbs.net/index.php/journal/article/view/321

Issue

Volume 1, Issue 2, 2010

Section

Research Articles