SERIAL ESTIMATION OF CA 15.3 CAN PREDICT THE OUTCOME IN PATIENTS WITH BREAST CANCER – A PROSPECTIVE STUDY.

Authors

  • SOUMI SAHA Comprehensive Breast Service & Breast Cancer Research Unit, Dept. of General Surgery, IPGME&R/SSKM Hospital, 244, A.J.C Bose Road. Kolkata-700020.
  • DR. VIKAS SINGH Comprehensive Breast Service & Breast Cancer Research Unit, Dept. of General Surgery, IPGME&R/SSKM Hospital, 244, A.J.C Bose Road. Kolkata-700020.
  • DR. SUVRO GANGULI Comprehensive Breast Service & Breast Cancer Research Unit, Dept. of General Surgery, IPGME&R/SSKM Hospital, 244, A.J.C Bose Road. Kolkata-700020.
  • DR. SOUMEN DAS Comprehensive Breast Service & Breast Cancer Research Unit, Dept. of General Surgery, IPGME&R/SSKM Hospital, 244, A.J.C Bose Road. Kolkata-700020.
  • DR. SHYAMSUNDAR MANDAL Department of Epidemiology & Bio-statistics, Chittaranjan National Cancer Institute, 37,S.P.Mukherjee Road, Kolkata-700027.
  • DR. DIPTENDRA K SARKAR Comprehensive Breast Service & Breast Cancer Research Unit, Dept. of General Surgery, IPGME&R/SSKM Hospital, 244, A.J.C Bose Road. Kolkata-700020.

Keywords:

Primary breast cancer, CA 15.3, Nottingham Prognostic Index, outcome

Abstract

CA 15.3 is widely applied for long term follow-up and monitoring therapy of breast cancer patients. The present study was conducted to assess the role of CA 15.3 in association with Nottingham Prognostic Index (NPI) to detect outcomes of breast cancer patients. Blood samples were collected from 85 nonmetastatic breast cancer patients and 57 patients with benign breast disease (BBD). CA 15.3 was measured from serum by ELISA. By comparing pre and post op CA 15.3 level, a significant decline in post op values were observed in majority of patients. NPI scores of patients were calculated. 18-24% of patients who had persistently elevated CA 15.3 in post-op follow-up and scored NPI>5.4, showed PO in term of recurrence/relapse/distant metastasis. Also PO (NPI>5.4) was correlated with large TS, different grades and with nodal metastasis. Raised post-op CA 15.3 along with high NPI can be predictive to derive outcome in breast cancer patients.

Downloads

Published

31.03.2014

How to Cite

SOUMI SAHA, DR. VIKAS SINGH, DR. SUVRO GANGULI, DR. SOUMEN DAS, DR. SHYAMSUNDAR MANDAL, & DR. DIPTENDRA K SARKAR. (2014). SERIAL ESTIMATION OF CA 15.3 CAN PREDICT THE OUTCOME IN PATIENTS WITH BREAST CANCER – A PROSPECTIVE STUDY. International Journal of Pharma and Bio Sciences, 5(1), 570–576. Retrieved from https://ijpbs.net/index.php/journal/article/view/3163

Issue

Volume 5, Issue 1, 2014

Section

Research Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.