ACUTE MYOCARDIAL INFARCTION- A CROSS SECTIONAL STUDY OF BIO-MARKERS

Abstract

Acute myocardial infarction (AMI) is diagnosed with history of chest pain, ECG, enzyme bio markers. Many persons may not present with typical chest pain and have atypical presentations.  Troponin-I is a polypeptide subunit of myofibrillar troponin complex. Troponin-I is present in both cardiac and skeletal muscles and that present in cardiac cell is known as cardiac specific protein Troponin-I. In cardiac tissue 97% of the protein is bound to myofibrills and 3% is found free in the cytosol of cardiomyocytes. An increase in the cardiac specific Troponin-I in the circulation is said to be a definitive marker of myocardial injury.The aim of the present study was to study the levels of various enzymatic markers in AMI and determine the efficacy of cTnI in terms of early detection when compared to that of the other know routine enzymatic markers of AMI. The present study included 50 cases with AMI and 40 control subjects.  We observed that within TnI was found to increase as early as 3 hrs from the onset of myocardial injury