Non-Template Synthesis and Antimicrobial Activities of Tetraazamacrocyclic Ligands with Variable Ring Sizes

Authors

  • NIRDOSH PATIL Department of Chemistry, Appa Institute of Engg. & Technology, Gulbarga-585103. Karnataka, India
  • RAMACHANDRA AKKASALI Department of Chemistry, Kottureswara College, Kottur, Bellary-583134, Karnataka, India

Keywords:

Ligands, Macro cycles, Anti-microbial, Diketones

Abstract

Three new macrocyclic ligands containing four aza groups have been prepared by the condensation reaction of 1-(2, 4-dihydroxyphenyl)-3-phynyl propane-1,3-dione with different diamines (1,2-diamino ethane, 1,3-diamino propane and 1,2-diamino benzene). The macrocycles prepared are “1,9-(2,4dihydroxyphenyl)-1,2-diphenyl-1,5,8,12-tetraazacyclotetradeca-1,4,z8,11-tetraene”, “4,10-di(2,4dihydroxyphenyl)-2,12-diphenyl-1,5,9,13-tetraazacyclohexadeca - 1,4,9,12-tetraene”  and     dibenzo-[b,I]4,9-di(2,4-dihydroxyphenyl)- 2, 11 -diphenyl - 1,5,8,12-tetraazacyclotetradeca-1,4,8,11-tetraene”. All the macrocyclic ligands were characterized by elemental analysis and IR, UV, NMR and mass spectral investigations and have been screened in vitro for their possible antimicrobial activity.  

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Published

30.06.2010

How to Cite

NIRDOSH PATIL, & RAMACHANDRA AKKASALI. (2010). Non-Template Synthesis and Antimicrobial Activities of Tetraazamacrocyclic Ligands with Variable Ring Sizes. International Journal of Pharma and Bio Sciences, 1(2), 1–6. Retrieved from https://ijpbs.net/index.php/journal/article/view/308

Issue

Volume 1, Issue 2, 2010

Section

Research Articles