SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NOVEL MANNICH BASES DERIVED FROM ΒETA-NAPHTHOL

Authors

  • K.CHAKKARAVARTHI PG and Research Department of Chemistry, PRIST University, Thanjavur, Tamil Nadu, India-614904
  • K.GOKULAKRISHNAN PG and Research Department of Chemistry, PRIST University, Thanjavur, Tamil Nadu, India-614904
  • T.SUMAN Department of Biotechnology, PRIST University, Thanjavur, Tamil Nadu, India-614904
  • D.TAMILVENDAN Department of Chemistry, National Institute of Technology, Trichirappalli, Tamil Nadu, India-620015

Keywords:

Mannich base, β-naphthol, p-toluidine, Benzimidazole, Antimicrobial activity, Antioxidant activity.

Abstract

This present study is concerned with the synthesis of novel β-naphthol Mannich bases with benzimidazole and p-toluidine by condensation reaction with appropriate aldehydes. The compounds 3-(phenyl(p-tolylamino)methyl) naphthalene-2-ol (TNPTB) and 3-((1H-benzo[d]imidazole-1-yl)methyl)naphthalene-2-ol (TNBIF) were synthesized and the chemical structures were characterized using spectral and analytical techniques. Mannich bases were screened for their antibacterial and antifungal activity against opportunistic bacterial and yeast pathogens. The antioxidant activity was tested using established methods. Among the tested ligands, TNBIF showed better  antimicrobial and antioxidant activity compared to TNPTB.

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Published

31.03.2014

How to Cite

K.CHAKKARAVARTHI, K.GOKULAKRISHNAN, T.SUMAN, & D.TAMILVENDAN. (2014). SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NOVEL MANNICH BASES DERIVED FROM ΒETA-NAPHTHOL. International Journal of Pharma and Bio Sciences, 5(1), 580–587. Retrieved from https://ijpbs.net/index.php/journal/article/view/3072

Issue

Volume 5, Issue 1, 2014

Section

Research Articles

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