POTENT IN-VITRO ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF PYRANO[2,3-D]PYRIMIDINE DERIVATIVES WITH QUANTITATIVE YIELD

Abstract

A series of Pyrano[2,3-d]Pyrimidine derivatives were synthesis using Knoevenagel and Michael addition reaction. Investigation of antimicrobial properties were done against gram positive bacteria Staphylococcus(NCTC-7447),Bacillus cereus(ATCC-14579) and gram  negative bacteria Serratia maresens(IMRU-70), Proteus merabitis (NTCC-289)  using Ampicillin as standard drugs. These synthesized compounds were also screened for their antifungal activity against two species of fungi Aspergillus ochraceus Wilhelm (AUCC-230 and Penicillium chrysogenum thom  (AUCC-530) using Mycostatin as standard drugs.  All the tested compounds shown moderate activity. The structures of the synthesized compounds were elucidated by spectral analysis (IR, 1HNMR and 13CNMR).