COMPARATIVE STUDY OF EFFECTS OF COMBINATION OF METFORMIN + GLIMEPIRIDE VS METFORMIN + GLIMEPIRIDE + PIOGLITAZONE IN TYPE 2 DIABETES MELLITUS PATIENTS.

Abstract

Metformin belongs to biguanides, Glimepiride is a second-generation sulfonylurea, Pioglitazone belongs to thiazolidinediones type of oral hypoglycaemic drugs. A prospective randomized open labelled parallel study was conducted in Type II Diabetes Mellitus patients. One group received Metformin and Glimepiride (M+G)   where as another group received Metformin, Glimepiride and Pioglitazone (M+G+P)   for 12 weeks. Baseline investigations were carried out before and after the study. The data was statistically analysed using students ‘T’ test. M+G+P group  showed a significant fall (p < 0.05)  in fasting and post prandial blood glucose , giycosylated haemoglobin (p < 0.05), significant rise ( p < 0.05)  in high density lipoprotein, better patient  compliance and follow up compared to M+G group. There was no significant difference in triglycerides, low density lipoprotein levels in both the groups.  Gastrointestinal side effects were more in M+G group while pedal oedema, hypoglycaemic episodes were more in M+G+P group.