ANTI-DIABETIC AND ANTI-INFLAMMATORY ACTIVITY OF CARALLUMA ADSCENDENS VAR. ADSCENDENS

Abstract

The plant Caralluma adscendens var. adscendens belongs to Asclepiadaceae family was taken for the evaluation of anti-diabetic and anti-inflammatory activity. Diabetes mellitus is a chronic disorder characterized by hyperglycemia with a disturbance of carbohydrate, protein and fat metabolism. Phytochemical screening of C. adscendens extract indicated the presence of several bioactive compounds like alkaloids, saponins, tannins, steroids, terpenoids, flavonoids and proteins. Anti-diabetic study was carried out by using the butanone extract and investigated using alloxan induced diabetic rats. The oral administration of extract at dose 500 mg/kg led to a significant blood glucose reduction. The anti-inflammatory activity of C. adscendens against carrageenan induced paw edema in albino rats was also carried out. The anti-inflammatory activity is more effective in carrageenan induction with oral administration of C. adscendens extract at dose 500 mg/kg body weight and the study was compared with standard drug Indomethacin (10mg/kg). The results showed that C. adscendens is having significant anti-diabetic and anti-inflammatory activity.