PON 1 ACTIVITY IN NEWLY DETECTED TYPE 2 DIABETES MELLITUS PATIENTS WITH & WITHOUT HYPERTENSION

Abstract

The prevalence of diabetes mellitus & hypertension has been increasing worldwide. Diabetes mellitus is an independent risk factor for coronary artery disease & risk is markedly increased when hypertension is present. Paraoxonase (PON1) is an HDL – associated esterase / lactonase & its activity is inversely related to the risk of cardiovascular disease. Antiatherogenic properties of PON1 include protection of LDL, HDL & macrophages against oxidation. Therefore we studied PON1 activity in newly detected type 2 diabetes mellitus with & without hypertension. We estimated the serum PON1 activity, total cholesterol, triacylglycerides, HDL-C & LDL-C in 100 newly detected type 2 diabetes mellitus with & without hypertension & 50 healthy controls. The result showed that PON1 & HDL-C were decreased & total cholesterol, triacylglycerides & LDL-C were increased in patients as compared to healthy controls. We suggest that PON1 activity decreased may be due to glycation of HDL as well as conformational changes in composition of HDL leading to detachment of PON1 itself from HDL in type 2 diabetes mellitus, resulting in inactivation of PON1. This indicates that PON1 may be very good predictor of coronary heart disease in type 2 diabetes mellitus.