STUDY THE EFFECT OF ACUTE LYMPHOBLASTIC LEUKEMIA ON ACID DNASE ACTIVITY IN CHILDREN

Abstract

Acute lymphoblastic leukemia (ALL) represents the malignant proliferation of lymphoid cells blocked at early stages of differentiation and is the most common malignancy in children. In patients with ALL, also numerous bone marrow stem cells grow into a type of white blood cell titled lymphocytes. These abnormal lymphocytes are not able to contest infection very well.aboratory investigations including serum total protein, serum acid DNase, Blood samples were collected from 60 patients diagnosed to Acute lymphoblastic leukemia (ALL) after one  month treatment with induction therapy. Age and sex matched 30 healthy persons selected as control. Activities and Specific Activities of Serum acid DNase showed  A significant increase in  patients group when compared to control group(p<0.001).In Conclusions Acid DNase  Activity may be a useful indicator of response to chemotherapy.