ENZYME INHIBITORS FROM PRUNUS PERSICA (L.) BATSCH: AN ALTERNATE APPROACH TO TREAT DIABETES

Abstract

In India, the prevalence of diabetes mellitus is alarmingly increasing and it is the need of the hour to be addressed appropriately. In this area of study, herbal remedies are considered to be the convenient method due to their traditional acceptability and availability, low costs, lesser side effects. Potent inhibitors found in some vegetables, herbs and fruits have been known to be effective for diabetes prevention. The ethanolic extract of the fruit was tested for their in vitro alpha amylase and glucosidase inhibitory activities to establish anti-diabetic potentials at digestive levels. Susceptibility of LDL oxidation was carried out to check the potency of the fruit to inhibit or decrease the susceptibility of LDL to its oxidized state. The inhibition to develop a free radical environment instead to pave way to bind to its active site and indulge in the formation of erythrocytes by the fruit extract was focused in haemoglobin glycosylation method. The hydrogen peroxide induced haemolysis exhibit rich antioxidative and protective effect of fruit extract to prevent diseases associated with oxidative stress. The result depicts the promising action of Prunus persica as an effective candidate in preventing the effects hyperglycemia.