CHRONOTHERAPEUTIC EFFECTS OF GALLIC ACID IN THE RENAL MARKERS, LIPID PEROXIDATION, ENZYMATIC ANTIOXIDANTS AND NON ENZYMATIC ANTIOXIDANT ON VANCOMYCIN INDUCED NEPHROTOXIC RATS

Authors

  • SADEESHKUMAR .V Department of Marine Biotechnology, CAS in Marine Biology, Annamalai University, India.

Keywords:

Chronotherapy, Gallic acid, Vancomycin, Nephrotoxicity, Wistar rats.

Abstract

The  present study investigates chronotherapeutic effects of renal markers and lipid peroxidation and antioxidant properties  in nephrotoxic rats, adult male albino Wistar rats, weighing 180-200 g with a nephrotoxic dose of vancomycin (200 mg/kg/body weight, twice a day(12 hour interval), i.p injection). This study used rats that were treated with 7 groups especially treatment group (GA + VAN) divided in to 4 groups (i.e 06:00hrs, 12:00hrs, 18:00hrs, 24:00hrs). Results showed that 24:00h time point level is peak when compared with other time points. The present study demonstrates that gallic acid can be protective against vancomycin -induced nephrotoxicity.

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Published

31.12.2013

How to Cite

SADEESHKUMAR .V. (2013). CHRONOTHERAPEUTIC EFFECTS OF GALLIC ACID IN THE RENAL MARKERS, LIPID PEROXIDATION, ENZYMATIC ANTIOXIDANTS AND NON ENZYMATIC ANTIOXIDANT ON VANCOMYCIN INDUCED NEPHROTOXIC RATS. International Journal of Pharma and Bio Sciences, 4(4), 289–298. Retrieved from https://ijpbs.net/index.php/journal/article/view/2868

Issue

Volume 4, Issue 4, 2013

Section

Research Articles

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