PUTATIVE DRUG TARGETS IN UREAPLASMA UREALYTICUM SEROVAR 10 STR. ATCC 33699 BY INSILICO GENOMICS APPROACH AND VIRTUAL SCREENING

Authors

  • VIJAYAKUMARI MALIPATIL Department of Bioinformatics, Karnataka State Women University, Bijapur, India.
  • SHIVKUMAR MADAGI Department of Bioinformatics, Karnataka State Women University, Bijapur, India.

Keywords:

Subtractive genomics, drug targets, natural compounds, docking, homology modeling.

Abstract

Increase in biological data at an alarming rate, has made possible the use of such data in identification of drug targets. Ureaplasma urealyticum serovar 10 str. ATCC 33699 is a causative agent for sexually transmitted infections. In present study novel comparative genomic approach is used to identify the drug targets. This approach has been successfully used in Pseudomonas aeroginosa. In current  study similar work has been done to mine the drug targets. Analysis in the present study showed a total of 265 essential proteins, out of which 14 showed pathways related to both human and pathogen. The 2 proteins are exclusively pathogen specific and are part of unique metabolic pathways. The 3-D structure of the drug targets was predicted by fold based method and virtual screening was performed to find the natural lead compounds that bind to target. ADME-tox properties of the natural compounds showing better binding affinity were also studied.

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Published

31.12.2013

How to Cite

VIJAYAKUMARI MALIPATIL, & SHIVKUMAR MADAGI. (2013). PUTATIVE DRUG TARGETS IN UREAPLASMA UREALYTICUM SEROVAR 10 STR. ATCC 33699 BY INSILICO GENOMICS APPROACH AND VIRTUAL SCREENING. International Journal of Pharma and Bio Sciences, 4(4), 214–221. Retrieved from https://ijpbs.net/index.php/journal/article/view/2856

Issue

Volume 4, Issue 4, 2013

Section

Research Articles

Categories

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