INFLUENCE OF GARLIC OIL ON ANTI DIABETIC ACTIVITY OF GLICLAZIDE IN DIABETIC RATS

Abstract

The objective of the present study is to examine the influence of garlic oil on the hypoglycaemic activity of gliclazide in alloxan induced diabetic rats. Albino rats were divided into five groups of six each. Group I animals served as normal control, group II animals served as diabetic control, group III animals treated with gliclazide, group IV animals treated with garlic oil and group V animals received both gliclazide and garlic oil. Blood samples were collected from rats and were analyzed blood glucose levels by GOD/POD method. Combination of gliclazide and garlic oil treated group showed significant reduction in percentage of blood glucose levels when compared to gliclazide only treated group. The present study suggests that during the simultaneous administration of gliclazide and garlic oil the dose and frequency of administration of gliclazide has to be readjusted accordingly in order to avoid severe hypoglycaemic complication due to the drug-drug interactions.