A NOVEL RP-HPLC METHOD FOR THE QUANTIFICATION OF RIVAROXABAN IN FORMULATIONS

Authors

  • DR. NALLAGATLA. VIJAYA BHASKAR RAO Principal, Govt.Degree College, Amrabad, Mahabubnagar.Dist, A.P, India, Pin: 509201. Micro Labs Limited-API, # 43-45 KIADB Industrial Area Phase-IV, Bommasandra, Bangalore- 560 105.
  • BRC SEKHAR REDDY Principal, Govt.Degree College, Amrabad, Mahabubnagar.Dist, A.P, India, Pin: 509201. Micro Labs Limited-API, # 43-45 KIADB Industrial Area Phase-IV, Bommasandra, Bangalore- 560 105.

Keywords:

Rivaroxaban, RP-HPLC, UV detection, recovery, precise, 273nm.

Abstract

A simple, precise and accurate RP-HPLC method was developed and validated for assay of Rivaroxaban in tablet dosage form. Isocratic elution at a flow rate of 1ml/min was employed on a Kromasil C18 (250x4.6mm, 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: Acetonitrile 80: 20 v/v, (PH 4.4). The UV detection wavelength was 273 nm and 20µl sample was injected. The retention time for Rivaroxaban was 5.35 min. The percentage RSD for precision and accuracy of the developed method was found to be less than 2%. The newly developed method was validated as per the ICH guidelines. The method was successfully applied for regular analysis of Rivaroxabanin in different formulations and bulk drug.

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Published

31.12.2013

How to Cite

DR. NALLAGATLA. VIJAYA BHASKAR RAO, & BRC SEKHAR REDDY. (2013). A NOVEL RP-HPLC METHOD FOR THE QUANTIFICATION OF RIVAROXABAN IN FORMULATIONS. International Journal of Pharma and Bio Sciences, 4(4), 756–764. Retrieved from https://ijpbs.net/index.php/journal/article/view/2806

Issue

Volume 4, Issue 4, 2013

Section

Research Articles

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