DESIGN, SYNTHESIS, ANTIMICROBIAL AND ANTI – INFLAMMATORY CTIVITIES OF SOME N-{3-[2-(SUBSTITUTED SULFANYL) –1H- ENZIMIDAZOL-1-YL]-4H (SUBSTITUTED)-1, 2, 4 – TRIAZOLE AND 2-(SUBSTITUTED SULFANYL)-1-[5-SUBSTITUTED -1, 3, 4 – OXADIAZOL -2-YL]-1HBENZIMIDAZOLE

Abstract

A Novel Series of Some substituted N-{3-[2-(substituted sulfanyl)-1H-benzimidazol-1-yl]-4H (substituted)-1,2,4-triazole and  2-(substituted sulfanyl)-1-[5-substituted -1, 3, 4-oxadiazol-2-yl]-1H-benzimidazole derivatives (A₁-A₉ & B₁-B₉) were prepared with the aim to get better antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activity. The structures of synthesized compounds were supported by means of IR, ¹H NMR and Mass spectroscopy. Title compounds were evaluated for antibacterial activity, antifungal activity, antitubercular and anti-inflammatory activities. Among the synthesized compounds ,some compounds found to possess all these activities. The QSAR study for anti imflamatory activity shows good results.