FORMULATION, CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDY OF GLIMEPIRIDE, Β-CYCLODEXTRINS INCLUSION COMPLEXES AND WATER SOLUBLE POLYMERS TERNARY SYSTEMS (the article is withdrawn)

Abstract

Through the years, β-cyclodextrins (BCDs) have been used in order to increase the
solubility of insoluble drugs in water. The aim of the present work was to improve the
solubility of glimepiride (GLIM), one of the third generation sulfonylurea used for
treatment of type 2 diabetes. Inclusion complexes of glimeperide (GLIM) in β-
cyclodextrin (BCD) and hydroxypropyl β-cyclodextrin (HPBCD) were prepared using
four different methods: physical mixture, kneading method, Freeze-drying and coevaporating
method with stoichiometric molar ratio 1:1; drug content estimation found
that co-evaporating is the best one of them. Characterizations of inclusion complexes
were carried out by the Fourier transform infrared spectroscopy (FTIR), Simultaneous
Thermogravimetry-Differential Scanning Calorimetry (TG-DSC) and X-rays diffraction
(XRD), these studies indicated the inclusion of glimeperide in the cavity of BCDs. The
ternary systems glimeperide, β-cyclodextrins inclusion complexes and water soluble
polymers (PEG 1500, PEG 4000, PEG 6000, PVP K30, PVP K90, HPC, and HPMC)
were prepared with the co-evaporating method. In-vitro dissolution study of pure drug
and all formulations have been released, the formulation which presents the best
dissolution rate was Glimeperide -Hydroxypropyl β-cyclodextrin-PEG 1500 ternary
system, the dissolution rate has attended more than 90%.