EVALUATION OF ANTI- INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES OF DIFFERENT EXTRACTS OF CLEOME CHELIDONII ROOT IN ALBINO RATS

Authors

  • SAMBASIVARAO ETHADI A.U College of Pharmaceutical Sciences, Andhra University,Visakhapatnam, A.P,India-530 003.
  • RAJESWARARAO PRAGADA A.U College of Pharmaceutical Sciences, Andhra University,Visakhapatnam, A.P,India-530 003.
  • GANGARAO BATTU A.U College of Pharmaceutical Sciences, Andhra University,Visakhapatnam, A.P,India-530 003.

Keywords:

Cleome chelidonii, Root, Anti-inflammatory, Hepatoprotective, Carbon Tetrachloride, Carrageenan, Oedema.

Abstract

The present study was carried out to evaluate the anti-inflammatory and hepatoprotective activities of different (Hydro-alcoholic, Methanolic, Ethylacetate, Hexane) extracts of Cleome chelidonii root against carrageenan induced inflammation and Carbon Tetrachloride (CCl4) induced liver intoxication in rats. The extracts of C.chelidonii root showed a dose dependent anti-inflammatory and hepatoprotection in rats. Among all the extracts, methanolic extracts produced maximum anti-inflammatorty activity (Percentage inhibition of maximal paw edema 53.39±1.2) and hepatoprotection (81.02%) at a dose of 400 mg/kg. The results were statistically significant (P<0.001) when compared to control group. The results of the present investigation clearly indicates that all the extracts of C.chelidonii root possess dose dependent anti-inflammatory, hepatoprotective activities and this effect may be the result of presence various chemical constituents.

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Published

31.12.2013

How to Cite

SAMBASIVARAO ETHADI, RAJESWARARAO PRAGADA, & GANGARAO BATTU. (2013). EVALUATION OF ANTI- INFLAMMATORY AND HEPATOPROTECTIVE ACTIVITIES OF DIFFERENT EXTRACTS OF CLEOME CHELIDONII ROOT IN ALBINO RATS. International Journal of Pharma and Bio Sciences, 4(4), 111–119. Retrieved from https://ijpbs.net/index.php/journal/article/view/2737

Issue

Volume 4, Issue 4, 2013

Section

Research Articles

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