PHARMACEUTICAL EVALUATION AND COMPARISON OF VARIOUS BRANDS OF PARACETAMOL TABLET FORMULATION.

Abstract

To compare the quality of the paracetamol tablet formulation manufactured by various multinational companies and local companies with international standards. The tablet formulations of ten different brands manufactured by MNC and local companies were tested for various parameters like hardness, friability, disintegration time, dissolution time, sedimentation, pH and dry weight using standard techniques .the values were compared with the standards. Wide variations in the parameters were seen in the tablet formulation manufactured by the local companies, where as the formulations manufactured by the MNC were comparable with standards. The manufacturing standards are not strictly followed by the local companies and there is need for proper monitoring.