ANTI TUMOUR EFFECT OF AQUEOUS EXTRACT FROM HELIX ASPERSA

Authors

  • IBTISSEM EL OUAR Laboratory of genie microbiology and application, University Constantine 1- road Ain el bey –Constantine-25000- Algeria
  • CORNELIA BRAICU Department of Functional Genomics and Experimental Pathology, Cancer Institute “Ion Chiricuta”, Cluj-Napoca, Romania
  • DALILA NAIMI Laboratory of genie microbiology and application, University Constantine 1- road Ain el bey –Constantine-25000- Algeria
  • ALEXENDRU IRIMIE Department of Surgery, University of Medicine and Pharmacy, “I. Hatieganu”, Cluj-Napoca, Romania, Department of Surgical Oncology, University of Medicine and Pharmacy, “I. Hatieganu”, Cluj-Napoca, Romania
  • IOANA BERINDAN-NEAGOE Department of Functional Genomics and Experimental Pathology, Cancer Institute “Ion Chiricuta”, Cluj-Napoca, RomaniaDepartment of Immunology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania

Keywords:

Helix aspersa, bioactive molecule, apoptosis, BcL2, tumour cells, Hs578T cell line.

Abstract

The garden snail Helix aspersa is a big land snail found widely in the Mediterranean countries; it has a high economic and nutritional value. The aim of this study is to investigate the anticancer activity of Helix aspersa extract against breast cancer cells Hs578T. Our assays showed that the extract had a high cytotoxicity against tumour cells; it acts by inducing necrosis and downregulating BcL2 expression. These results are novel and demonstrate that H. aspersa extract may serve as a source of a new anticancer drug or as an associated treatment in chemotherapy that inhibits BcL2 expression.

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Published

30.09.2013

How to Cite

IBTISSEM EL OUAR, CORNELIA BRAICU, DALILA NAIMI, ALEXENDRU IRIMIE, & IOANA BERINDAN-NEAGOE. (2013). ANTI TUMOUR EFFECT OF AQUEOUS EXTRACT FROM HELIX ASPERSA. International Journal of Pharma and Bio Sciences, 4(3), 1325–1332. Retrieved from https://ijpbs.net/index.php/journal/article/view/2710

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

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