ESTIMATED GLOMERULAR FILTRATION RATE AS AN EARLY MARKER OF RENAL FUNCTION IMPAIRMENT IN APPARENTLY HEALTHY INDIVIDUALS WITH NORMAL SERUM CREATININE LEVELS: A COMPARISON OF VARIOUS EQUATIONS

Abstract

This study was done to assess the renal function in normal healthy individuals with normal serum creatinine levels, on the basis of estimated glomerular filtration rate (eGFR) and to compare and correlate eGFR obtained by various formulae. The mean eGFR reduced with an increase in age. There was a reduction in eGFR in 44.5% of subjects as calculated by Modification of Diet in Renal Disease study (MDRD) equation.  The eGFR values calculated by MDRD, Chronic Kidney Disease Epidemiology equation (CKD EPI) and Mayo Clinic Quadratic equation (MCQ) were comparable. Stage 3 chronic kidney disease by both MDRD and CKD EPI formula was 5.2%, whereas by MCQ formula it was 0.4%. eGFR appears to be a predictive diagnostic marker of early stages of renal dysfunction  in otherwise normal apparently healthy individuals with normal serum creatinine.