NARINGIN AMELIORATES RENAL IMPAIRMENT ON CYCLOSPORINE (A)-INDUCED NEPHROTOXICITY IN RATS: INVOLVEMENT OF iNOS

Authors

  • YAMINI CHANDRAMOHAN Post-Graduate Department of Biochemistry, Bharathi Women’s College (Autonomous), Prakasam Salai, North Chennai 600 108, Tamil Nadu, India
  • CHETENCHERY SOMASUNDARAM PARAMESWARI Post-Graduate Department of Biochemistry, Bharathi Women’s College (Autonomous), Prakasam Salai, North Chennai 600 108, Tamil Nadu, India

Keywords:

Renoprotection, CyclosporineA (CsA), Naringin (NG), lactate dehydrogenase, inducible nitric oxide synthase (iNOS)

Abstract

The therapeutic effecicacy of a flavonoid Naringin (NG) against Cyclosporine A (CsA) induced nephrotoxicity was investigated in this study. Nephrotoxicity was induced in male albino wistar rats by injecting 25mg/kg body weight of CsA for a period of 21 days. CsA induced rats were also cotreated with 40mg of Naringin (NG/kg body weight) orally. After the experimental period the serum levels of urea, uric acid and creatinine were found to be elevated, followed by the decrease in creatinine clearance, whereas the levels of ALP, ACP were increased in serum of CsA induced rats. A significant decrease in LDH levels were observed in CsA induced animals compared to control. Immunohistochemical staining of inducible nitric oxide synthase (iNOS) expression was studied and NG co treatment significantly decreased the expression of iNOS in CsA challenged rats. This data was further evidenced by western blotting expression pattern of iNOS in experimental rats.

Downloads

Published

30.09.2013

How to Cite

YAMINI CHANDRAMOHAN, & CHETENCHERY SOMASUNDARAM PARAMESWARI. (2013). NARINGIN AMELIORATES RENAL IMPAIRMENT ON CYCLOSPORINE (A)-INDUCED NEPHROTOXICITY IN RATS: INVOLVEMENT OF iNOS. International Journal of Pharma and Bio Sciences, 4(3), 414–421. Retrieved from https://ijpbs.net/index.php/journal/article/view/2592

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

Categories

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.