SYNTHESIS OF 14-MEMBERED TETRAAZAMACROCYCLIC COMPLEXES AND THEIR PHYSICO-CHEMICAL CHARACTERIZATIONS AND BIOLOGICAL SCREENING.

Abstract

Complexes of Co(II), Ni(II),  and Cu(II) containing macrocyclic tetradentate nitrogen donor (N4) ligand have been synthesized from the template condensation reaction between substituted benzil and ethylenediamine(EDA)  The newly synthesized ligands [N₄L¹] and [N₄L²] and its complexes have been characterized  by elemental analyses, molar conductance measurement, magnetic susceptibility measurements, FTIR, electronic and EPR spectral. The spectral data suggested hexa co-ordinated state for these complexes. Conductivity data suggested that they behave as non-electrolytes. Based on spectral  studies, an octahedral geometry has been proposed for Co(II), Ni(II) complexes but a distorted octahedral geometry for Cu(II) complexes respectively. The ligand and their complexes have been screened in vitro against pathogenic fungi and bacteria to assess their growth inhibiting potential.