MICRO-DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES USING ICP-ATOMIC EMISSIO SPECTROMETRY

Authors

  • SABRY KHALIL Medical Laboratories Department, College of Applied Medical Science, Taif University, Taif 21944, P.O. Box 2425, KSA. Chemistry Department, Faculty of Science, Fayoum University, Egypt.

Keywords:

Pharmaceutical analysis, ion-associate complexes, ICP-atomic emission spectrometry.

Abstract

Ion-associate complexes of Itopride hydrochloride with zinc(II) thiocyanate, sodium cobaltinitrite and ammonium reineckate are precipitated. The solubility of the ion associates at the optimum pH and ionic strength values have been examined. Saturated solutions were prepared at differ­ent temperatures ( 25 – 60oC ) under the optimum precipitation conditions and the metal ion contents ( zinc, chromium and cobalt ) in the supernatant were determined. The solubility products were thus calcu­lated at different  temperatures and the thermodynamic parameters ΔH, ΔG and ΔS were calculated. A new accurate and precise method based on inductively coupled plasma atomic emission spectrometry  for the micro-determination of Itopride hydrochloride (0.63-71.08 μg/ml) in pure solutions, pharmaceutical formulations and urine samples is given.

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Published

30.09.2013

How to Cite

SABRY KHALIL. (2013). MICRO-DETERMINATION OF ITOPRIDE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS AND URINE SAMPLES USING ICP-ATOMIC EMISSIO SPECTROMETRY. International Journal of Pharma and Bio Sciences, 4(3), 786–794. Retrieved from https://ijpbs.net/index.php/journal/article/view/2512

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

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