PREPARATIVE ISOLATION OF FLAVONOIDS FROM WATTAKAKA VOLUBILIS(LINN.F.) LEAF EXTRACTS AND ITS ROLE AS ANTIMITOTIC AND ANTIPROLIFERATING AGENT

Abstract

A large number of medicinal plants have therapeutic potentials. In this study polyphenolic extracts from leaves of Wattakaka volubilis have been applied for HPLC, which reports the presence of seven flavonoids. Extracts have been tested for antimitotic and antiproliferating activities. Allium cepa root tips were been used to evaluate cytotoxicity. Polyphenolic and methanolic extracts were toxic on roots number, root length and also reduced the mitotic index. Extracts also showed significant results on antiproliferating activity in yeast model.