SYNTHESIS, SPECTRAL CHARACTERIZATION AND BIOLOGICAL STUDIES OF NOVEL SCHIFF BASE COMPLEXES DERIVED FROM 4,6-DIMETHYL-2- SULFANILAMIDOPYRIMIDINE AND 2-HYDROXY-3-METHOXYBENZALDEHYDE

Abstract

New Schiff base has been prepared from 4,6-Dimethyl-2-Sulfanilamidopyrimidine  and 2-hydroxy-3-methoxy benzaldehyde in ethanolic media and then complexed with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) ions. The synthesized ligand and complexes were characterised by Elemental analysis, Molar conductance , Magnetic susceptibility, IR, UV,¹H & ¹³C NMR and EPR spectral studies.  The reasonable shifts of FT-IR and NMR spectral signals of the complexes with respect to the free ligand confirm well coordination of Schiff-base ligand with the metal through imine nitrogen and oxygen atoms of Schiff base moiety. The Schiff base ligand and the complexes were screened for antimicrobial activity.  From the analytical and spectral data, the stoichiometry has been found to be 1:2 for all the complexes.  An octahedral structure has been proposed. All the new complexes were found to be active against bacteria and fungi.