SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE STUDIES OF Fe(III) AND Zn(II) COMPLEXES CONTAINING MIXED LIGANDS

Authors

  • B.SREEKANTH Departmentof Biotechnology, Acharya Institute of Technology,Bangalore - 560 090, Karnataka, India.
  • G.KRISHNAMURTHY Department of Chemistry, Sahyadri Science College, Shimoga, Karnataka, India.
  • H.S.BHOJYANAIK Department of PG Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577 451, Shimoga, Karnataka.
  • S.M.GOPINATH Departmentof Biotechnology, Acharya Institute of Technology,Bangalore - 560 090, Karnataka, India.
  • T.K.VISHNUVARDHAN Department of Chemistry, Acharya Institute of Technology, Bangalore - 560 090, Karnataka, India.
  • M.ISMAIL SHAREEF Departmentof Biotechnology, Acharya Institute of Technology,Bangalore - 560 090, Karnataka, India.

Keywords:

Fe(III) and Zn(II) complexes; DNA binding; viscosity measurements; thermal denaturation; cleavage studies.

Abstract

The newly synthesized mixed complexes of the type [Fe(L1L2L3)] (PF6)3 complex (1), [Zn(L1L2L3)] (PF6)2 complex (2), (where  L1 = 1, 10-phenanthroline and L2 = 1H-benzimidazole-2-thiol and L3 = 4H-1,2,4-triazol-4-amine) were characterized by elemental analysis IR, UV and NMR spectral studies.The DNA interactions of complex (1) and complex (2) was determined by absorption spectral studies. The results of binding constant indicate that all the complexes intercalate with CT-DNA. The relative nuclease activity of these complexes were studied by gel electrophoresis using pUC 19 DNA.

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Published

30.09.2013

How to Cite

B.SREEKANTH, G.KRISHNAMURTHY, H.S.BHOJYANAIK, S.M.GOPINATH, T.K.VISHNUVARDHAN, & M.ISMAIL SHAREEF. (2013). SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE STUDIES OF Fe(III) AND Zn(II) COMPLEXES CONTAINING MIXED LIGANDS. International Journal of Pharma and Bio Sciences, 4(3), 257–265. Retrieved from https://ijpbs.net/index.php/journal/article/view/2457

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

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