ACCELERATED RECOVERY OF 5-FLUOROURACIL-DAMAGED BONE MARROW AFTER OXYTOCIN TREATMENT

Authors

  • SHADAN MUSLIM ALJANABI Damascus University, Collage of pharmacy, Pharmacology Department
  • SHAZA AL-LAHAM Damascus University, Collage of pharmacy, Pharmacology Department
  • ADNAN M. EKHTIAR Syrian Atomic Energy Commission, Biotechnology Department

Keywords:

Oxytocin, Myeloprotective, Medium size cells, 5-Fluorouracil

Abstract

Our preliminary data indicate that Oxytocin may be myeloprotective. We investigated whether it can modify bone marrow recovery. Oxytocin (150 µg/kg) accelerated the recovery of the number of medium size cells (MI%) and platelets (PLT) but did not affect the number of circulating red blood cells (RBC) and total count of white blood cells (WBC).Oxytocin injected subcutaneously for 5 consecutive days at doses of 150 µg/kg (twice a day) after 5-FU single dose. Glutathione GSH  (anti-oxidant) has preventive effects against 5-FU-induced myelosuppression and can accelerate recovery of bone marrow. Oxytocin only increase GSH levels insignificantly (P > 0.05).These findings suggest that Oxytocinselectively enhances the recovery of the population of progenitor cells reduced by 5-FU in rats.

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Published

30.09.2013

How to Cite

SHADAN MUSLIM ALJANABI, SHAZA AL-LAHAM, & ADNAN M. EKHTIAR. (2013). ACCELERATED RECOVERY OF 5-FLUOROURACIL-DAMAGED BONE MARROW AFTER OXYTOCIN TREATMENT. International Journal of Pharma and Bio Sciences, 4(3), 223–227. Retrieved from https://ijpbs.net/index.php/journal/article/view/2453

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

Categories

License

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