ANTIULCER AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF C.HIRSUTUS AGAINST ETHANOL INDUCED GASTRIC ULCER IN ALBINO RATS

Authors

  • D.SWATHI Scient Institute of Pharmacy, Ibrahimpatnam.,Hyderabad.,Andhra Pradesh., India..
  • K.V.S.R.G.PRASAD Institute of pharmaceutical technology,SPMVV., Tirupati..
  • P.RAMYA SREE. Scient Institute of Pharmacy, Ibrahimpatnam.,Hyderabad.,Andhra Pradesh., India..
  • M.JALAIAH Scient Institute of Pharmacy, Ibrahimpatnam.,Hyderabad.,Andhra Pradesh., India..

Keywords:

Cocculus hirsutus, Ulcer index, Lipid peroxidation, Catalase, Nitrite

Abstract

The ethanolic extract of roots of Cocculus hirsutus has been useful of various ailments (Tuberculosis, leprosy, skin diseases, dyspepsia, pruritis etc.). To determine the gastroprotective effect of Cocculus hirsutus in model of ethanol induced ulcer rat, the ethanolic extract is given by oral gauges (100mg/kg) and (200mg/kg) half an hour prior to the administration of ethanol (1 ml of 96%).The antioxidant parameters were also determined in this model. C.hirsutus treatment significantly reduced the ulcer index, lipid peroxidation (LPO) and significant increase in catalase, nitrite , thereby justifying it’s use as an anti ulcerogenic agent.

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Published

30.09.2013

How to Cite

D.SWATHI, K.V.S.R.G.PRASAD, P.RAMYA SREE., & M.JALAIAH. (2013). ANTIULCER AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF C.HIRSUTUS AGAINST ETHANOL INDUCED GASTRIC ULCER IN ALBINO RATS. International Journal of Pharma and Bio Sciences, 4(3), 74–78. Retrieved from https://ijpbs.net/index.php/journal/article/view/2433

Issue

Volume 4, Issue 3, 2013

Section

Research Articles

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