INHIBITIVE ENHANCEMENT OF ISONIASID TREATMENT ON MYCOBACTERIUM TUBERCULOSIS THROUGH TRITERPENOID CARBOCYLIC ACID FROM RED ALGAE EUCHEMA SPINOSUM

Authors

  • AHYAR AHMAD Lab. of Biochemistry and Bioorganic, Department of Chemistry, Faculty of Natural Sciences, Hasanuddin University, Makassar, 90245 Indonesia
  • MUH. NASRUM MASSI Department of Microbiology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, 90245 Indonesia

Keywords:

Red algae, Euchema spinosum, Triterpenoid carbocylic acid, Antimycobacterial activity.

Abstract

Anti-mycobacterial bioactivity of non polar compounds from red algae Euchema spinosum of Barang Lompo Island was studied. A triterpenoid carbocylic  acid has been isolated from the chloroform fraction of Euchema spinosum, and its structure was determined by spectroscopic evidences including IR and 2D NMR and compared to previous data. The isolate was active against Mycobacterium tuberculosis at concentration 4 µg/mL, and  could also increase the sensitivity of this pathogen to isoniasid drug. These studies suggest that anti-mycobacterial triterpenoid carbocylic  acid in combination with isoniasid may play an important role in host defence against M. tuberculosis strain H37Rv.

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Published

30.06.2013

How to Cite

AHYAR AHMAD, & MUH. NASRUM MASSI. (2013). INHIBITIVE ENHANCEMENT OF ISONIASID TREATMENT ON MYCOBACTERIUM TUBERCULOSIS THROUGH TRITERPENOID CARBOCYLIC ACID FROM RED ALGAE EUCHEMA SPINOSUM. International Journal of Pharma and Bio Sciences, 4(2), 231–237. Retrieved from https://ijpbs.net/index.php/journal/article/view/2289

Issue

Volume 4, Issue 2, 2013

Section

Research Articles

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