Potent Selective Cytotoxic Activity of Kaempferia Galanga L. Rhizome Against Cancer Cell Cultures

Authors

  • JAGADISH P.C. Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, Karnataka, India
  • RAGHU CHANDRASHEKHAR H. Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576 104, Karnataka, India
  • VINOD KUMAR S. Dabur Research Foundation, Ghaziabad 201 010, Uttar Pradesh, India
  • LATHA K.P. Sahyadri Science College, Shimoga 577 201, Karnataka, India

Keywords:

Cytotoxicity, MTT assay, SRB assay, Kaemperia galanga

Abstract

Crude ethanol extract of the rhizome Kaempferia galanga L. and the successive extracts prepared with increasing polarity viz., petroleum ether, ethyl acetate and ethanol. The extracts and fractions were screened for cytotoxic activities by standard MTT and SRB assays against four cancerous viz., DU145, PA1, SW620, B16F10 and a normal Vero cell cultures. The successive ethyl acetate extract showed selective toxicity towards cancer cells and showed less toxicity towards normal cells. The successive petroleum ether fraction showed potent activity against human colorectal adenocarcinoma cells with CTC50 0.55 µg/ml and was comparatively non toxic towards normal Vero cell cultures. 

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Published

30.06.2010

How to Cite

JAGADISH P.C., RAGHU CHANDRASHEKHAR H., VINOD KUMAR S., & LATHA K.P. (2010). Potent Selective Cytotoxic Activity of Kaempferia Galanga L. Rhizome Against Cancer Cell Cultures. International Journal of Pharma and Bio Sciences, 1(2), 1–5. Retrieved from https://ijpbs.net/index.php/journal/article/view/222

Issue

Volume 1, Issue 2, 2010

Section

Research Articles