CLINICAL EVALUATION OF ANTI-HYPERGLYCEMIC ACTIVITY OF OCIMUM SANCTUM IN COMPARISON WITH GLIBENCLAMIDE IN THE RAT MODEL OF T2DM
Keywords:
Anti-hyperglycemic,Ocimum sanctum, Glibenclamide, T2DMAbstract
India leads the world in total number of diabetic cases with the estimate of 50.8 million
adult populations in 2010. Overall predicted increase in number from 2010 to 2030 is
54% at an annual growth of 2.2%, which is nearly twice the annual growth of total world
population. Hyperglycemia or high blood sugar is a condition in which an excessive
amount of glucose circulates in the blood. Diabetes Mellitus is one such important
disease and characterized by chronic hyperglycemia with disturbances of carbohydrate,
fat and protein metabolism resulting from defects in insulin secretion, insulin action or
both. Ocimum sanctum is a herb and found throughout the India, with several medicinal
and religious purposes and for its essential oils and also possesses anti-hyperglycemic
activity. Only a very few studies have been done on this plant to establish their antihyperglycemic
property. The purpose of this study is to evaluate the anti-hyperglycemic
activity of Ocimum sanctum in the rat model of Diabetes Mellitus Type-2.
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