SCREENING FOR ANTIOXIDANT ACTIVITY IN TRADITIONALLY USED MEDICINAL HERBS: COMPARISON OF TOTAL PHENOLS, RADICAL SCAVENGING AND DNA DAMAGE PROTECTING ACTIVITY

Authors

  • RACHNA GARG Department of Microbiology and Biotechnology, Bangalore University, Bangalore 560056, Karnataka, India
  • DEVIHALLI CHIKKAIAH MOHANA Department of Microbiology and Biotechnology, Bangalore University, Bangalore 560056, Karnataka, India
  • KIRAGANDUR MANJUNATH Department of Microbiology and Biotechnology, Bangalore University, Bangalore 560056, Karnataka, India

Keywords:

Antioxidant activity,Total phenolic content, Radical scavenging activity,Oxidative DNA damage, Correlation analysis.

Abstract

Herbal infusions of nine traditionally used medicinal plants were screened for total phenolic content (TPC), radical scavenging activity (RSA) and oxidative DNA damage protecting capacity by chemical assays. The TPC was determined in order to know its correlation with RSA. The extracts of T. cordifolia and C. spectabilis presented highest TPC values (34.21 ± 0.93 and 28.36 ± 1.05 mg GAE/g) and showed strong RSA (96.29 ± 0.91 and 84.68 ± 0.90 mg TE/g). A significant relationship (R2 = 0.915, p< 0.01) was found between TPC and RSA indicating that phenolics are contributing to the antioxidant properties of these plants. The qualitative analysis of DNA damage protecting activity revealed the potential of T. cordifolia, V. negundo, O. sanctum and C. phlomides extracts as potent DNA damage protecting agent. Present study validates the uses of these herbs in various herbal ailments to treat many illnesses associated with oxidative stress.

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Published

30.06.2013

How to Cite

RACHNA GARG, DEVIHALLI CHIKKAIAH MOHANA, & KIRAGANDUR MANJUNATH. (2013). SCREENING FOR ANTIOXIDANT ACTIVITY IN TRADITIONALLY USED MEDICINAL HERBS: COMPARISON OF TOTAL PHENOLS, RADICAL SCAVENGING AND DNA DAMAGE PROTECTING ACTIVITY. International Journal of Pharma and Bio Sciences, 4(2), 657–664. Retrieved from https://ijpbs.net/index.php/journal/article/view/2213

Issue

Volume 4, Issue 2, 2013

Section

Research Articles

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