A NEW APPROACH TO ANTI-HIV CHEMOTHERAPY DEVISED BY LINKING THE VITAL FRAGMENTS OF ACTIVE RT INHIBITORS SUCH AS ETRAVIRINE TO THE MOLECULAR FRAMEWORK OF ANTI-HIV PRONE PRIVILEGED NUCLEUS OF 1,4-BENZODIAZEPINE AS POSSIBLE SUBSTITUTE TO 'HAART'

Abstract

In the anticipation of finding potential substitutes of highly active antiretroviral therapy [HAART], several molecular probes (9-12) have been developed by incorporating the vital fragments of RT inhibitor ‘etravirine’ to the anti-HIV prone privileged template of 1,4-benzodiazepine (2), on the premise that their presence in tandem in the same molecular framework could produce a positive impact in overcoming the problem arising due to the emergence of the multidrug resistant mutants of the virus.