MOLECULAR DOCKING STUDIES, SYNTHESIS AND ANTI-BACTERIAL PROPERTIES OF NEW MANNICH BASES

Authors

  • ONKARA.P Department of BiotechnologyWarangal- 506 004, (A.P.), India
  • A.SUNIL KUMAR Department of ChemistryWarangal- 506 004, (A.P.), India
  • S.KANAKARAJU Department of ChemistryWarangal- 506 004, (A.P.), India
  • B.PRASANNA Department of ChemistryWarangal- 506 004, (A.P.), India
  • Y.PYDISETTY Department of Chemical Engineering,National Institute of Technology, Warangal- 506 004, (A.P.), India
  • G.V.P.CHANDRAMOULI Department of BiotechnologyWarangal- 506 004, (A.P.), India

Keywords:

4-Hydroxy coumarin, Mannich base, Ionic liquid, Molecular docking, Antibacterial activity

Abstract

A series of 3-substituted aminophenyl-4-hydroxycoumarins 4a-h were synthesized via Mannich reaction by using [BMIM]BF4 ionic liquid under microwave irradiation. Compounds were characterized by IR, 1H NMR and mass spectroscopy. All the compounds were tested for their antibacterial activity against B.subtilis, Bacillus.sp, E. coli and P.putida. Most of the compounds showed moderate to good antibacterial activity. Docking studies of the synthesized compounds was done with the help of VLife MDS 3.5 software using GA docking method to study their observed activity.

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Published

30.06.2013

How to Cite

ONKARA.P, A.SUNIL KUMAR, S.KANAKARAJU, B.PRASANNA, Y.PYDISETTY, & G.V.P.CHANDRAMOULI. (2013). MOLECULAR DOCKING STUDIES, SYNTHESIS AND ANTI-BACTERIAL PROPERTIES OF NEW MANNICH BASES. International Journal of Pharma and Bio Sciences, 4(2), 263–270. Retrieved from https://ijpbs.net/index.php/journal/article/view/2169

Issue

Volume 4, Issue 2, 2013

Section

Research Articles

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