EVALUATION OF ANTI-ULCER ACTIVITY OF TINOSPORA CORDIFOLIA IN ALBINO RATS

Abstract

This study was conducted to evaluate anti-ulcer activity of Tinospora cordifolia in albino rats. Albino rats of  wistar variety of either sex weighing 140-165gms were evenly divided into different treatment groups. The aqueous extract of Tinospora cordifolia was investigated for its anti- ulcer activity against pylorus ligation, aspirin induced and ethanol induced gastric ulcer in rats at 400mg/kg body weight p.o. In pylorus ligated rats, Tinospora cordifolia extract has shown significant (P<0.01) reduction in gastric volume, total acidity & ulcer index as compared to control. There was also significant (P<0.01)  reduction in ulcer index seen among Tinospora cordifolia extract treated rats of aspirin and ethanol induced models. The anti-ulcer activity was further confirmed by histopathological examination of rat stomach. Thus the present study concludes  Tinospora cordifolia extract having potential anti- ulcer activity in the three models tested.