TITRIMETRIC ANALYSIS OF KETOPROFEN IN THE BULK DRUG SAMPLE USING SODIUM CITRATE AS HYDROTROPIC AGENT

Authors

  • RAJESH KUMAR MAHESHWARI Department of Pharmacy, Shri G. S. Institute of Technology and Science, Indore, India
  • SHEKHAR KUMAR College of Pharmacy, IPS Academy, Rajendra Nagar, A. B. Road, Indore, India
  • NEHA BHAWSAR College of Pharmacy, IPS Academy, Rajendra Nagar, A. B. Road, Indore, India
  • AASIF ANSARI Acropolis Institute of Pharmaceutical education and Research, Indore, India

Keywords:

Keoprofen, Hydrotropy, sodium citrate, solubility enhancement.

Abstract

The present investigation illustrates the application of hydrotropy. There was a miraculous synergistic effect on enhancement in solubility of a practically water insoluble drug by using hydrotropic agents. The enhancement in the solubility of ketoprofen by using hydrotropic solution 1.25 M sodium citrate was more than 180 fold (as compared to the solubility in distilled water). This proved a synergistic enhancement in solubility of a practically water insoluble drug due to hydrotropy.  Hydrotropic agent was employed to solublize a practically water insoluble drug, ketoprofen, in bulk to carry out titrimetric analysis precluding the use of organic solvents. The bulk containing ketoprofen was analyzed successfully. Statistical data proved accuracy, reproducibility and the precision of the proposed method. The presenter of hydrotropic agents (sodium citrate) did not interfere with the analysis.

Downloads

Published

30.06.2013

How to Cite

RAJESH KUMAR MAHESHWARI, SHEKHAR KUMAR, NEHA BHAWSAR, & AASIF ANSARI. (2013). TITRIMETRIC ANALYSIS OF KETOPROFEN IN THE BULK DRUG SAMPLE USING SODIUM CITRATE AS HYDROTROPIC AGENT. International Journal of Pharma and Bio Sciences, 4(2), 58–61. Retrieved from https://ijpbs.net/index.php/journal/article/view/2144

Issue

Volume 4, Issue 2, 2013

Section

Research Articles

Categories